Nabota® (Prabotulinumtoxin A) is a U.S. FDA approved botulinum toxin. Botulinum toxin can help in softening, minimizing the appearance of lines and wrinkles caused by facial expressions to bring about a more youthful appearance. Regulated amounts of botulinum toxin have also been used safely to treat a variety of conditions, including muscle spasms, twitching, and excessive sweating (hyperhidrosis). 

1.) U.S. FDA approved 900kDa botulinum toxin. This is the most complex molecular size, which is also the most stable and effective.

2.)  Toxin with rapid onset (2 days) with proven effectiveness

3.)  High purity toxin containing >98% of the 900 kDa botulinum toxin resulted from the patented Hi-PURE technology 

4.) Efficacy and safety data in large-scale global clinical studies with more than 2000 patients 

 Nabota® temporarily restricts your nerves from telling your facial muscles to flex. This in turn helps to temporarily improve the appearance of moderate to severe frown lines.

The following list are contraindications for Nabota®

• Patients with known hypersensitivity or allergic reactions to this product.
• Patients who have neuromuscular junctional disorders (e.g. myasthenia gravis, Lambert-Eaton syndrome, or amyotrophic lateral sclerosis) who may experience exacerbated weakness due to muscle relaxation properties of this product.
• Pregnant women and nursing mothers.
• Infection or inflammation at the proposed injection sites.

What Are the Results with Nabota®?

Large-scale global clinical studies for more than 2000 patients were carried out in the US and Europe which showed that Nabota® temporarily improved the appearance of moderate to severe frown lines (glabellar lines). More than 67.5% of patients responded with an improvement in composite score of 2 or more in the Glabellar Line Scale (GLS).6 GLS is used to determine the severity of glabellar lines, where 0 – none, 1 – mild, 2 – moderate, 3 – severe. Another study conducted in Europe and Canada reported that both subjects and investigators were satisfied with Nabota® at all time points – Day 90, Day 120, and Day 150 – based on the Global Aesthetic Improvement Scale (GAIS).7 GAIS is a 5-point scale for assessing global aesthetic improvement in appearance compared to pre-treatment, where 2 – much improved, 1 – improved, 0 – no change, -1 – worse, -2 – much worse. Nabota is also proven to be non-inferior to Onabotulinumtoxin A7, and has studies to support its long-term efficacy for an improvement in composite score of 2 or more in GLS.